EFFECTS OF CENTRAL DEPRESSANT DRUGS UPON ACETYLCHOLINE RELEASE
نویسندگان
چکیده
منابع مشابه
Effects of CNS depressant drugs on mouse encephalomyelitis virus.
Previous work (Pearson, 1950; Pearson et al., 1952; and Visser et al., 1952) showed that various compounds may inhibit Theiler's GDVII strain of mouse encephalomyelitis virs in vitro; none tested so far was effective in vivo. It was of interest to determine if compounds capable of depressing centrl nervous stem activity would also repress virl activity. The present report gives the results of t...
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BACKGROUND Effects of orally administered daytime melatonin on novelty induced behaviors and spatial working memory in mice were evaluated using the open field, the Y maze and the radial arm maze. PURPOSE To ascertain the possible nootropic and/or central excitatory or inhibitory effects of daytime oral melatonin in mice. METHODS Adult male mice from our colony, assigned to three and four g...
متن کاملOpposite effects of depressant and convulsant barbiturate stereoisomers on acetylcholine release from the rat hippocampus in vivo.
BACKGROUND It has been shown that the R(-) isomer of 1-methyl-5-phenyl-5-propyl barbituric acid (MPPB) induces loss of the righting reflex (LRR), while S(+)-MPPB causes pure excitatory effects, including convulsions, in vivo. METHODS We studied the effects of the depressant and convulsant MPPB stereoisomers on rat hippocampal acetylcholine (ACh) release in vivo, using a brain microdialysis te...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1964
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1964.tb02047.x